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Oral Fluid Drug and Alcohol Screen Device

Package Insert for the

AMP/mAMP/COC/OPI/THC/PCP/BZO/OXY/MTD/BAR/BUP/ACL

Test for Oral Fluids

A rapid, screening test for the simultaneous, qualitative detection of Amphetamine, Methamphetamine, Cocaine, Opiates, Marijuana Phencyclidine Benzodiazepines Oxycodone, Methadone, .3 Barbiturates, Buprenorphine, Alcohol and their metabolites in human oral fluid.

For Forensic Use Only

INTENDED USE

The Salivaconfirm premium ™ Oral Fluid Drug and Alcohol Screen Device for AMP/mAMP/COC/OPI/THC/PCP/BZO/OXY/MTD/BAR/BUP/ACL is a lateral flow chromatographic immunoassay for the qualitative detection of Amphetamine, Methamphetamine, Cocaine, Opiates, Marijuana, Phencyclidine, Benzodiazepines, Oxycodone, Methadone Barbiturates, Buprenorphine, Alcohol and their metabolites in oral fluids at the following cut-off concentrations

Test

Calibrator

Cut-off

Amphetamine (AMP) D-Amphetamine 50 ng/mL
Methamphetamine (mAMP) D-Methamphetamine 50 ng/mL
Cocaine (COC) Benzoylecgonine 20 ng/mL
Opiates (OPI) Morphine 40 ng/mL
Opiates (OPI) Morphine 40 ng/mL
Marijuana (THC) 11-nor-∆9-THC-9 COOH 12 ng/mL
9-THC 75 ng/mL
Phencyclidine (PCP) Phencyclidine 10 ng/mL
Benzodiazepines (BZO) Oxazepam 50 ng/mL
Oxycodone(OXY) Oxycodone 50 ng/mL
Methadone(MTD) Methadone 75 ng/mL
Barbiturates (BAR) Secobarbital 300 ng/mL
Buprenorphine (BUP) Buprenorphine 10 ng/mL
Alcohol(ACL) Alcohol > 0.02 % B.A.C

This assay provides only a preliminary analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. Gas chromatography/mass spectrometry (GC/MS) and gas chromatography/tandem mass spectrometry (GC/MS/MS) are the preferred confirmatory methods. Professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are indicated.

SUMMARY AND EXPLANATION OF THE TEST

The Saliva Confirm Fluid Drug and Alcohol Screen Device for AMP/mAMP/COC/OPI/THC/PCP/BZO/OXY/MTD/BAR/BUP/ACL and their metabolites is a rapid, oral fluid screening test that can be performed without the use of an instrument. The test utilizes monoclonal antibodies to selectively detect elevated levels of specific drugs in human oral fluid.

AMPHETAMINE(AMP)

Amphetamine is a sympathomimetic amine with therapeutic indications. The drug is often selfadministered by nasal inhalation or oral ingestion. Depending on the route of administration, Amphetamine can be detected in oral fluid as early as 5-10 minutes and up to 72 hours after use1.

The Amphetamine assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the Amphetamine concentration in oral fluid exceeds 50ng/mL.

METHAMPHETAMINE (mAMP)

Methamphetamine is a potent stimulant chemically related to amphetamine but with greater CNS stimulation properties. The drug is often self-administered by nasal inhalation, smoking or oral ingestion. Depending on the route of administration, methamphetamine can be detected in oral fluid as early as 5-10 minutes and up to 72 hours after use1.

The Methamphetamine assay contained within the Oral Cube™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the Methamphetamine concentration in oral fluid exceeds 50 ng/mL.

COCAINE (COC)

Cocaine is a potent central nervous system (CNS) stimulant and a local anesthetic derived from the coca plant (erythroxylum coca). The drug is often self-administered by nasal inhalation, intravenous injection and free-base smoking. Depending on the route of administration, cocaine and metabolites benzoylecgonine and ecgonine methyl ester can be detected in oral fluid as early as 5-10 minutes following use1. Cocaine and benzoylecgonine can be detected in oral fluids for up to 24 hours after use1.

The Cocaine assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the cocaine metabolite in oral fluid exceeds 20 ng/mL.

OPIATE (OPI)

The drug class opiates refers to any drug that is derived from the opium poppy, including naturally occurring compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, nausea and irritability. Opiates can be taken orally or by injection routes including intravenous, intramuscular and subcutaneous; illegal users may also take the intravenously or by nasal inhalation. Using an immunoassay cutoff level of 40 ng/mL, codeine can be detected in the oral fluid within 1 hour following a single oral dose and can remain detectable for 7-21 hours after the dose2. 6-monoacetylmorphine (6-MAM) is found more prevalently in oral fluid, and is a metabolic product of heroin. Morphine is the major metabolic product of codeine and heroin, and is detectable for 24-48 hours after an opiate dose.

The Opiates assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the concentration of Morphine in oral fluid exceeds the 40 ng/mL cut-off level.

MARIJUANA (THC)

Tetrahydrocannabinol, the active ingredient in the marijuana plant (cannabis sativa), is detectable in saliva shortly after use. The detection of the drug is thought to be primarily due to the direct exposure of the drug to the mouth (oral and smoking administrations) and the subsequent sequestering of the drug in the buccal cavity3. Historical studies have shown a window of detection for THC in saliva of up to 14 hours after drug use3.

The Marijuana assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the 11-nor-Δ9-THC-9 COOH concentration exceeds 12 ng/mL.

The Marijuana assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the Δ9-THC concentration exceeds 75 ng/mL.

PHENCYCLIDINE (PCP)

Phencyclidine, the hallucinogen commonly referred to as Angel Dust, can be detected in saliva as a result of the exchange of the drug between the circulatory system and the oral cavity. In a paired serum and saliva sample collection of 100 patients in an Emergency Department, PCP was detected in the saliva of 79 patients at levels as low as 2 ng/mL and as high as 600 ng/mL4.

The Phencyclidine assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the Phencyclidine concentration in oral fluids exceeds 10 ng/mL.

BENZODIAZEPINES(BZO)

Benzodiazepines are frequently prescribed sedative and hypnotic drug for the symptomatic treatment of anxiety, insomnia, sleep and seizure disorders. Most Benzodiazepines are extensively metabolized in the liver and excreted in the urine and saliva as metabolites. Chronic abuse may increase the risk of physical dependence and may result in intoxication, drowsiness and muscle relaxation. Oxazepam is the major metabolic product of Benzodiazepines.

The Benzodiazepines assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the concentration of Oxazepam in oral fluids exceeds 50 ng/mL.

Oxycodone(OXY)

Oxycodone is a semi-synthetic opioid with a structural similarity to codeine. The drug is manufactured by modifying thebaine, an alkaloid found in the opium poppy. Oxycodone, like all opiate agonists, provides pain relief by acting on opioid receptors in the spinal cord, brain, and possibly directly in the affected tissues. Oxycodone is prescribed for the relief of moderate to high pain under the well-known pharmaceutical trade names of OxyContin®, Tylox®, Percodan® and Percocet®. While Tylox, Percodan and Percocet contain only small doses of oxycodone hydrochloride combined with other analgesics such as acetaminophen or aspirin, OxyContin consists solely of oxycodone hydrochloride in a time-release form.

The Oxycodone assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the concentration of oxycodone in oral fluid exceeds 50 ng/mL.

METHADONE(MTD)

Methadone is a narcotic analgesic prescribed for the management of moderate to severe pain and for the treatment of opiate dependence (heroin, Vicodin, Percocet, morphine). The pharmacology of oral methadone is very different from IV methadone. Oral methadone is partially stored in the liver for later use. IV methadone acts more like heroin. In most states you must go to a pain clinic or a methadone maintenance clinic to be prescribed methadone.

Methadone is a long acting pain reliever producing effects that last from twelve to forty-eight hours. Ideally, methadone frees the client from the pressures of obtaining illegal heroin, from the dangers of injection, and from the emotional roller coaster that most opiates produce. Methadone, if taken for long periods and at large doses, can lead to a very long withdrawal period. The withdrawals from methadone are more prolonged and troublesome than those provoked by heroin cessation, yet the substitution and phased removal of methadone is an acceptable method of detoxification for patients and therapists5.

The Methadone assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the Methadone concentration in oral fluids exceeds 75 ng/mL.

BARBITURATES (BAR)

Barbiturates are CNS depressants. They are used therapeutically as sedatives, hypnotics, and anticonvulsants. Barbiturates are almost always taken orally as capsules or tablets. The effects resemble those of intoxication with alcohol. Chronic use of barbiturates leads to tolerance and physical dependence.
Short-acting barbiturates taken at 400 mg/day for 2-3 months can produce a clinically significant degree of physical dependence. Withdrawal symptoms experienced during periods of drug abstinence can be severe enough to cause death.
Only a small amount (less than 5%) of most barbiturates are excreted unaltered in the urine.
The approximate detection time limits for barbiturates are:

Short acting (e.g. Secobarbital) 100 mg PO (oral) 4.5 days

Long acting (e.g. Phenobarbital) 400 mg PO (oral) 7 days5

The Barbiturates assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the Barbiturates concentration in oral fluid exceeds 300 ng/mL.

BUPRENORPHINE (BUP)

Buprenorphine is a potent analgesic often used in the treatment of opioid addiction. The drug is sold under the trade names Subutex™, Buprenex™, Temgesic™ and Suboxone™, which contain
Buprenorphine HCl alone or in combination with Naloxone HCl. Therapeutically, Buprenorphine is used as a substitution treatment for opioid addicts. Substitution treatment is a form of medical care offered to opiate addicts (primarily heroin addicts) based on a similar or identical substance to the drug normally used. In substitution therapy, Buprenorphine is as effective as Methadone but demonstrates a lower level of physical dependence.

Substantial abuse of Buprenorphine has also been reported in many countries where various forms of the drug are available. The drug has been diverted from legitimate channels through theft, doctor shopping, and fraudulent prescriptions, and been abused via intravenous, sublingual, intranasal and inhalation routes.

The Buprenorphine assay contained within the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device yields a positive result when the Buprenorphine concentration in oral fluid exceeds 10 ng/mL.

ALCOHOL(ACL)

Alcohol intoxication can lead to loss of alertness, coma, death and as well as birth defects. The BAC at which a person becomes impaired is variable. The United States Department of Transportation (DOT) has established a BAC of 0.02% (0.02g/dL) as the cut-off level at which an individual is considered positive for the presence of alcohol.

PRINCIPLE

  1. The Oral Fluid Drug and Alcohol Screen Device for AMP/mAMP/COC/OPI/THC/PCP/BZO/OXY/MTD/BAR/BUP is an immunoassay based on the principle of competitive binding. Drugs that may be present in the oral fluid specimen compete against their respective drug conjugate for binding sites on their specific antibody.

    During testing, a portion of the oral fluid specimen migrates upward by capillary action. A drug, if present in the oral fluid specimen below its cut-off concentration, will not saturate the binding sites of its specific antibody. The antibody will then react with the drug-protein conjugate and a visible colored line will show up in the test line region of the specific drug strip. The presence of drug above the cut-off concentration in the oral fluid specimen will saturate all the binding sites of the antibody. Therefore, the colored line will not form in the test line region.

    A drug-positive oral fluid specimen will not generate a colored line in the specific test line region of the strip because of drug competition, while a drug-negative oral fluid specimen will generate a line in the test line region because of the absence of drug competition.

    To serve as a procedural control, a colored line will always appear at the control line region, indicating that proper volume of specimen has been added and membrane wicking has occurred.

  2. Alcohol Test: A pad coated with enzymes, turns to color shades of green and blue on contact with alcohol in the oral fluids. The alcohol pad employs a solid phase chemistry which uses the following highly specific enzymatic reaction:

    CH3CH2OH + O2 Alcohol Oxidase
    H
    CH3C=O + H2O2
    H2O2 + DH2 Peroxidase
    D + 2H2O
    Blue

    During testing, oral fluid is collected on the alcohol pad and saturates the alcohol pad. If no alcohol is present in the oral fluid, the alcohol pad remains colorless (remains white or cream color) because there is no alcohol in the oral fluid to react with enzymes to start the color reaction. If alcohol is present in the oral fluid, the alcohol pad changes to green or blue color because the alcohol reacts with alcohol oxidaze to produce aldehyde and peroxide. The peroxide reacts with peroxidase in the presence of hydrogen donor to produce a blue color. Therefore, the presence of green to blue color at the alcohol pad window indicates a presumptive positive result for alcohol.

REAGENT

  1. The test contains membrane strips coated with drug- protein conjugates (purified bovine albumin) on the test line, a goat polyclonal antibody against gold-protein conjugate at the control line, and a dye pad which contains colloidal gold particles coated with mouse monoclonal antibody specific to Amphetamine, Methamphetamine, Benzoylecgonine, Morphine, Marijuana, Phencyclidine, Oxazepam, Oxycodone, Methadone, Barbiturates and Buprenorphine.

  2. Alcohol Test: The alcohol pad contains Tetramethylbenzidine, Alcohol Oxidaze, Peroxidase, Buffer and Stabilizing Proteins

PRECAUTIONS

  • For Forensic Use Only.

  • Do not use after the expiration date.

  • The Oral Fluid Drug Screen Device should remain in the sealed pouch until use.

  • Saliva is not classified as biological hazard unless derived from a dental procedure.

  • The test device is for single use.

  • The used collector and device should be discarded according to federal, state and local regulations.

STORAGTE AND STABILITY

Store as packaged in the sealed pouch at 2-30°C. The test is stable through the expiration date printed on the sealed pouch. The test devices must remain in the sealed pouch until use. DO NOT FREEZE. Do not use beyond the expiration date.

SPECIMEN COLLECTION AND PREPARATION

The oral fluid specimen should be collected using the collector provided with the kit. Follow the detailed Directions for Use below. No other collection devices should be used with this assay. Oral fluid collected at any time of the day may be used.

Materials

Materials Provided

  • Test devices

  • Package insert

  • Procedure Card

Materials Required But Not Provided

  • Timer

DIRECTIONS FOR USE

Allow the test device to reach room temperature [15-30°C (59-86°F)] prior to testing. Do not place anything in the mouth including food, drink, gum, or tobacco products for at least 10 minutes prior to collection of oral fluid specimen.

  1. Remove the collection stick and test tube from the sealed pouch.

  2. Tear off the package of the collection stick. (Step 1)

  3. Insert the sponge end of the collection stick into mouth and soak sponge into saliva for 3 minutes. (Note: Time should be longer for people of little saliva. If the amount of saliva pressed into the test tube is not adequate for testing, collect more with another new collection stick and express the saliva into tube again.). (Step 2)

  4. Hold the test tube vertically and place the collection stick with saturated sponge into the test tube. Make sure to fit the groove of collection stick onto the guide rail of test tube and press the collection stick to full extent. (Step 3)

  5. Press down the lid to close the test tube. Keep the test tube vertically until you begin to read the test results. (Step 4)

  6. Read results of alcohol test at 2 minutes and drug tests at 10 miuntes.(If there is a label over reading window, peel off the label to read test results.)Do not read alcohol test result after 5 minutes and drug test results after 1 hour.(Step 5)

  7. Send the collector with collected oral fluid to the laboratory for GC/MS confirmation if necessary.

INTERPRETATION OF RESULTS

(Please refer to the previous illustration)

NEGATIVE:

Two lines appear. * One color line should be in the control region (C), and another apparent color line adjacent should be in the test region (T). This negative result indicates that the drug concentration is below the detectable level.

*NOTE: The shade of color in the test line region (T) will vary, but it should be considered negative whenever there is even a faint distinguishable color line.

POSITIVE:

One color line appears in the control region (C). No line appears in the test region (T). This positive result indicates that the drug concentration is above the detectable level.

INVALID:

Control line fails to appear. Insufficient specimen volume or incorrect procedural techniques are the most likely reasons for control line failure. Review the procedure and repeat the test using a new test device. If the problem persists, discontinue using the lot immediately and contact your supplier.

Alcohol Test Results

Alcohol Negative Result: The alcohol pad shows no color change (remains white or cream colored); it should be interpreted as a negative result (no alcohol present). A result where the outer edges of the alcohol pad produces a slight color but the majority of the pad remains colorless should be repeated to ensure complete saturation of the alcohol pad with oral fluid. If the second result is the same, the results should be interpreted as being negative (no alcohol present).

Alcohol Presumptive Positive Result: The Alcohol test produces a color change to green to blue in the presence of salivary alcohol 0.02 % B.A.C. or higher. At higher alcohol concentration near 0.30% B.A.C., the color may change to a dark blue-gray.

QUALITY CONTROL

A procedural control is included in the test. A color line appearing in the control region (C) is considered an internal procedural control. It confirms sufficient specimen volume, adequate membrane wicking and correct procedural technique.

LIMITATIONS

  1. The Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device provides only a qualitative, preliminary analytical result. A secondary analytical method must be used to obtain a confirmed result. Gas chromatography/mass spectrometry (GC/MS) or gas chromatography/tandem mass spectrometry (GC/MS/MS) is preferred confirmatory methods.

  2. A positive test result does not indicate the concentration of drug in the specimen or the route of administration.

  3. A negative result may not necessarily indicate a drug-free specimen. Drug may be present in the specimen below the cutoff level of the assay.

PERFORMANCE CHARACTERISTICS

Analytical Sensitivity

A Phosphate-buffered saline (PBS) pool was spiked with drugs to target concentrations of ± 50% cut-off and ± 25% cut-off and tested with the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device. The results are summarized below.

Drug concentration
Cut-off Range
n AMP mAMP COC OPI THC PCP BZO OXY MTD BAR BUP
- + - + - + - + - + - + - + - + - + - + - +
0% Cut-off 30 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0
-50% Cut-off 30 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0
-25% Cut-off 30 28 2 29 1 30 0 27 3 27 3 30 0 28 2 28 2 29 1 29 1 27 3
Cut-off 30 13 17 16 14 19 11 18 12 14 16 20 10 13 17 12 18 10 20 12 18 16 14
+25% Cut-off 30 4 26 7 23 5 25 3 27 1 29 7 23 4 28 3 27 2 28 3 27 7 23
+50% Cut-off 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30 0 30

For the alcohol test, saliva was obtained by rinsing with positive ethanol control solutions at various B.A.C. (0.02%, 0.08%, 0.15%, 0.30%,). Negative saliva was used to test at 0% concentration. For each concentration, a total of 15 tests were performed to validate the test performance. The results of the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device are summarized below:

Test Total # of Test/Concentration B.A.C.
0.00% 0.02% 0.08% 0.15% 0.30%
- + - + - + - + - +
Alcohol 15 15 0 1 14 0 15 0 15 0 15

Analytical Specificity

The following table lists the concentration of compounds (ng/mL) above which the Salivaconfirm premium™ Oral Fluid Drug and Alcohol Screen Device for AMP/mAMP/COC/OPI/THC/PCP/BZO/OXY/MTD/BAR/BUP identified positive results at a read time of 10 minutes.

Drug

Concentration (ng/ml)

AMPHETAMINE (AMP)

D-Amphetamine 50
DL-Amphetamine 125
ß-Phenylethylamine 4,000
(+)3,4-Methylenedioxyamphetamine (MDA) 150
L-Amphetamine 4,000
p-Hydroxyamphetamine 800
Tryptamine 1,500

METHAMPHETAMINE (mAMP)

(1R,2S) - (-) Ephedrine 400
Fenfluramine 60,000
Codeine 25,000
Dihydrocodeine 6,250
Ethylmorphine 12,500
Hydrocodone 1,000
Hydromorphone 6,250
Oxymorphone 1,000
Thebaine 25,000

MARIJUANA (THC)

11-nor-Δ9 -THC-9 COOH 12
Cannabinol 3,000
Δ8 -THC 75
Δ9 -THC 75

METHADONE(MTD)

Methadone 75
Doxylamine 12,500
Doxylamine 12,500

BARBITURATES (BAR)

Alphenol 150
Amobarbital 300
Aprobarbital 200
Butabarbital 75
Butalbital 2,500
Butethal 100
Cyclopentobarbital 600
Pentobarbital 300
Phenobarbital 100
Secobarbital 300

BUPRENORPHINE(BUP)

Norbuprenorphine 10
Buprenorphine 20
3-D-glucuronide 15
Norbuprenglucuronide 200

Alcohol Test

The Alcohol test will react with methyl, ethyl,and allyl alcohols, but it will not react with alcohols having 5 or more carbons, glycine, glycerol, and serine. This property is a result of specificity of the alcohol oxidase enzyme extracted from yeast.

NON CROSS-REACTIVITY

A study was conducted to determine the cross-reactivity of the test with compounds spiked into drug-free PBS stock. The following compounds demonstrated no false positive results on the Salivaconfirm premiumΔ Oral Fluid Drug and Alcohol Screen Device when tested with concentrations up to 100 μg/mL.

Acetaminophen Benzoic acid D/L-Octopamine
Acetophenetidin Benzphetamine Creatinine
N-Acetylprocainamide D/L-Brompheniramine Deoxycorticosterone
Acetylsalicylic acid   Dextromethorphan
Aminopyrine Caffeine Diclofenac
Amoxicillin Cannabidol Diflunisal
Ampicillin Chloralhydrate Digoxin
L-Ascorbic acid Chloramphenicol Diphenhydramine
Apomorphine Chlorothiazide L-Y-Ephedrine
Aspartame D/L-Chloropheniramine ß-Estradiol
Atropine Chlorpromazine Estrone-3-sulfate
Cholesterol Chloroquine Ethyl-p-aminobenzoate
Clonidine Norethindrone L(-)-Epinephrine
Cortisone D-Norpropoxyphene Erythromycin
L-Cotinine Noscapine Fenoprofen
Furosemide Naltrexone Quindine
Gentisic acid Naproxen Ranitidine
Hemoglobin Niacinamide Salicylic acid
Hydralazine NifedipineOxalic acid Serotonin
Hydrochlorothiazide Oxolinic acid Sulfamethazine
Hydrocortisone Oxymetazoline Sulindac
O-Hydroxyhippuric acid Papaverine Tetracycline
p-Hydroxytyramine Penicillin-G Tetrahydrocortisone 3-acetate
Ibuprofen Pentazocine hydrochloride Tetrahydrocortisone 3 (ß-D-glucuronide)
Iproniazid Perphenazine Thiamine
D/L-Isoproterenol Phenelzine Thioridazine
Isoxsuprine Trans-2-phenylcyclopropylamine D/L-Tyrosine
Ketamine hydrochloride Tolbutamide
Ketoprofen Phenylpropanolamine Triamterene
Labetalol Prednisolone Trifluoperazine
Loperamide Prednisone Trimethoprim
Meperidine D/L-Propranolol D/L-Tryptophan
Meprobamate D-Propoxyphene Tyramine
Methylphenidate D-Pseudoephedrine Uric acid
Nalidixic acid Quinacrine Verapamil
Naloxone Quinine Zomepirac

Alcohol Test

The following substances may interfere with the Salivaconfirm premiumTM Oral Fluid Drug and Alcohol Screen Device when using samples other than oral fluid:

  1. Agents which enhance color development:
    Peroxides and strong oxidizers

  2. Agents which inhibit color development:
    Reducing Agents: such as Ascorbic acid, Tannic Acid, Pyrogallol, Mercaptanalics and tosylates, Oxalic acid, Uric acid, Bilirubin, L-methyldopa, L-dopa, L-methyldopa, and Methampyrone, etc.
    The above-named substances do not normally appear in sufficient quantity in oral fluid to interfere with the test. However, care must be taken that they are not introduced into the mouth during the 10 minutes period preceding the test.

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